Drug interactions
Chlordiazepoxide + Protriptyline
Severity: Moderate
Chlordiazepoxide and Protriptyline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can cause sedation, and protriptyline adds anticholinergic and psychomotor effects. Together they may impair alertness and coordination, although protriptyline is less sedating than other tricyclics.
What this interaction means in plain words
Chlordiazepoxide and Protriptyline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression and psychomotor impairment; chlordiazepoxide may modestly affect tricyclic effects.
What to do
Monitor for drowsiness, dizziness and falls, especially in older adults. Reduce doses if excessive sedation occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chlordiazepoxide
Frequently asked questions
Can I take Chlordiazepoxide with Protriptyline?
MediHelp rates the interaction as moderate. Chlordiazepoxide and Protriptyline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can cause sedation, and protriptyline adds anticholinergic and psychomotor effects. Together they may impair alertness and coordination, although protriptyline is less sedating than other tricyclics.
How serious is the interaction between Chlordiazepoxide and Protriptyline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for drowsiness, dizziness and falls, especially in older adults. Reduce doses if excessive sedation occurs.
What other medicines interact with Chlordiazepoxide?
MediHelp also lists interactions of Chlordiazepoxide with, for example, Alfentanil, Alprazolam, Amobarbital. The full list is on the Chlordiazepoxide page.
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