Drug interactions
Chlordiazepoxide + Quazepam
Severity: Major
Chlordiazepoxide and Quazepam: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Two benzodiazepines used together increase sedation, psychomotor impairment and respiratory depression risk without added therapeutic benefit. Both have long-acting active metabolites, so effects can accumulate and persist.
What this interaction means in plain words
Chlordiazepoxide and Quazepam can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive GABA-A receptor potentiation producing CNS depression.
What to do
Avoid duplicate benzodiazepine therapy and consolidate to a single agent. If a transition is required, taper one agent and monitor for oversedation.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Chlordiazepoxide
Frequently asked questions
Can I take Chlordiazepoxide with Quazepam?
MediHelp rates the interaction as major. Chlordiazepoxide and Quazepam can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Two benzodiazepines used together increase sedation, psychomotor impairment and respiratory depression risk without added therapeutic benefit. Both have long-acting active metabolites, so effects can accumulate and persist.
How serious is the interaction between Chlordiazepoxide and Quazepam?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid duplicate benzodiazepine therapy and consolidate to a single agent. If a transition is required, taper one agent and monitor for oversedation.
What other medicines interact with Chlordiazepoxide?
MediHelp also lists interactions of Chlordiazepoxide with, for example, Alfentanil, Alprazolam, Amobarbital. The full list is on the Chlordiazepoxide page.
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