Drug interactions
Chlordiazepoxide + Triazolam
Severity: Major
Chlordiazepoxide and Triazolam: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining two benzodiazepines increases sedation, amnesia, impaired coordination and respiratory depression without therapeutic gain. Older adults are at particular risk of falls and confusion.
What this interaction means in plain words
Chlordiazepoxide and Triazolam can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive GABA-A receptor potentiation producing CNS depression.
What to do
Avoid duplicate benzodiazepine therapy and use a single agent. If both are temporarily required, use the lowest doses and monitor sedation.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Chlordiazepoxide
Frequently asked questions
Can I take Chlordiazepoxide with Triazolam?
MediHelp rates the interaction as major. Chlordiazepoxide and Triazolam can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Combining two benzodiazepines increases sedation, amnesia, impaired coordination and respiratory depression without therapeutic gain. Older adults are at particular risk of falls and confusion.
How serious is the interaction between Chlordiazepoxide and Triazolam?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid duplicate benzodiazepine therapy and use a single agent. If both are temporarily required, use the lowest doses and monitor sedation.
What other medicines interact with Chlordiazepoxide?
MediHelp also lists interactions of Chlordiazepoxide with, for example, Alfentanil, Alprazolam, Amobarbital. The full list is on the Chlordiazepoxide page.
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