Drug interactions
Chlordiazepoxide + Valerian
Severity: Moderate
Chlordiazepoxide and Valerian: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Valerian has sedative properties and may add to the sedative effects of chlordiazepoxide. This may increase drowsiness and impair psychomotor performance, although the clinical evidence is limited.
What this interaction means in plain words
Chlordiazepoxide and Valerian can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression, as valerian constituents are thought to modulate GABA-A receptor activity.
What to do
Advise patients to avoid valerian products while taking chlordiazepoxide, or monitor for excess sedation. Counsel against driving or operating machinery.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chlordiazepoxide
Frequently asked questions
Can I take Chlordiazepoxide with Valerian?
MediHelp rates the interaction as moderate. Chlordiazepoxide and Valerian can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Valerian has sedative properties and may add to the sedative effects of chlordiazepoxide. This may increase drowsiness and impair psychomotor performance, although the clinical evidence is limited.
How serious is the interaction between Chlordiazepoxide and Valerian?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise patients to avoid valerian products while taking chlordiazepoxide, or monitor for excess sedation. Counsel against driving or operating machinery.
What other medicines interact with Chlordiazepoxide?
MediHelp also lists interactions of Chlordiazepoxide with, for example, Alfentanil, Alprazolam, Amobarbital. The full list is on the Chlordiazepoxide page.
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