Drug interactions
Chlordiazepoxide + Yohimbine
Severity: Minor
Chlordiazepoxide and Yohimbine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Chlordiazepoxide causes sedation while yohimbine is an alpha-2 antagonist with stimulant and anxiogenic properties. Yohimbine may blunt the calming effect of the benzodiazepine, but the net effect is unpredictable.
What this interaction means in plain words
Chlordiazepoxide and Yohimbine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Opposing pharmacodynamic effects on CNS arousal; no established pharmacokinetic mechanism.
What to do
Monitor the patient for reduced anxiolytic effect or unexpected agitation and adjust the benzodiazepine dose only if clinically needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Chlordiazepoxide
Frequently asked questions
Can I take Chlordiazepoxide with Yohimbine?
MediHelp rates the interaction as minor. Chlordiazepoxide and Yohimbine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Chlordiazepoxide causes sedation while yohimbine is an alpha-2 antagonist with stimulant and anxiogenic properties. Yohimbine may blunt the calming effect of the benzodiazepine, but the net effect is unpredictable.
How serious is the interaction between Chlordiazepoxide and Yohimbine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor the patient for reduced anxiolytic effect or unexpected agitation and adjust the benzodiazepine dose only if clinically needed.
What other medicines interact with Chlordiazepoxide?
MediHelp also lists interactions of Chlordiazepoxide with, for example, Alfentanil, Alprazolam, Amobarbital. The full list is on the Chlordiazepoxide page.
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