Drug interactions
Chlordiazepoxide + Zolpidem
Severity: Moderate
Chlordiazepoxide and Zolpidem: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining zolpidem with a benzodiazepine increases sedation and impairs psychomotor function and memory. Risk of complex sleep behaviors, falls, and respiratory depression rises, especially in older adults.
What this interaction means in plain words
Chlordiazepoxide and Zolpidem can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chlordiazepoxide belongs to Central Nervous System; Zolpidem belongs to Central Nervous System.
Why it happens
Additive enhancement of GABA-A receptor mediated CNS depression.
What to do
Avoid combining where possible; if both are needed, use the lowest doses and monitor for oversedation and respiratory depression. Counsel against driving and alcohol.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chlordiazepoxide
Other interactions of Zolpidem
Frequently asked questions
Can I take Chlordiazepoxide with Zolpidem?
MediHelp rates the interaction as moderate. Chlordiazepoxide and Zolpidem can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Combining zolpidem with a benzodiazepine increases sedation and impairs psychomotor function and memory. Risk of complex sleep behaviors, falls, and respiratory depression rises, especially in older adults.
How serious is the interaction between Chlordiazepoxide and Zolpidem?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining where possible; if both are needed, use the lowest doses and monitor for oversedation and respiratory depression. Counsel against driving and alcohol.
What other medicines interact with Chlordiazepoxide?
MediHelp also lists interactions of Chlordiazepoxide with, for example, Alfentanil, Alprazolam, Amobarbital. The full list is on the Chlordiazepoxide page.
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