Drug interactions
Chlordiazepoxide + Zotepine
Severity: Moderate
Chlordiazepoxide and Zotepine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Zotepine is a sedating antipsychotic and adds to the CNS depression produced by chlordiazepoxide. This can lead to marked drowsiness, impaired psychomotor performance and hypotension.
What this interaction means in plain words
Chlordiazepoxide and Zotepine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression through GABA-A potentiation and antihistaminic/antiadrenergic antipsychotic effects.
What to do
Monitor sedation and blood pressure, start with low doses and counsel patients to avoid driving or operating machinery.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chlordiazepoxide
Frequently asked questions
Can I take Chlordiazepoxide with Zotepine?
MediHelp rates the interaction as moderate. Chlordiazepoxide and Zotepine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Zotepine is a sedating antipsychotic and adds to the CNS depression produced by chlordiazepoxide. This can lead to marked drowsiness, impaired psychomotor performance and hypotension.
How serious is the interaction between Chlordiazepoxide and Zotepine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation and blood pressure, start with low doses and counsel patients to avoid driving or operating machinery.
What other medicines interact with Chlordiazepoxide?
MediHelp also lists interactions of Chlordiazepoxide with, for example, Alfentanil, Alprazolam, Amobarbital. The full list is on the Chlordiazepoxide page.
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