Drug interactions
Cholera vaccine + Fluorouracil
Severity: Minor
Cholera vaccine and Fluorouracil: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Systemic fluorouracil is myelosuppressive and can lower antibody responses to vaccines, so the cholera vaccine may give reduced protection during chemotherapy.
What this interaction means in plain words
Cholera vaccine and Fluorouracil have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Cytotoxic immunosuppression impairs the immune response to vaccination.
What to do
Where feasible, vaccinate before chemotherapy or between cycles, and do not rely on full protection when given during therapy.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Fluorouracil
Frequently asked questions
Can I take Cholera vaccine with Fluorouracil?
MediHelp rates the interaction as minor. Cholera vaccine and Fluorouracil have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Systemic fluorouracil is myelosuppressive and can lower antibody responses to vaccines, so the cholera vaccine may give reduced protection during chemotherapy.
How serious is the interaction between Cholera vaccine and Fluorouracil?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Where feasible, vaccinate before chemotherapy or between cycles, and do not rely on full protection when given during therapy.
What other medicines interact with Fluorouracil?
MediHelp also lists interactions of Fluorouracil with, for example, Adenovirus types 4 and 7 live, Axicabtagene ciloleucel, Belatacept. The full list is on the Fluorouracil page.
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