Drug interactions
Cholera vaccine + Hydrocortisone
Severity: Moderate
Cholera vaccine and Hydrocortisone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Immunosuppressive doses of corticosteroids can blunt the antibody response to vaccines. Oral cholera vaccine may therefore give weaker protection in patients on high-dose or prolonged hydrocortisone.
What this interaction means in plain words
Cholera vaccine and Hydrocortisone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Corticosteroid-induced immunosuppression reduces vaccine immune response.
What to do
Vaccinate before starting immunosuppressive corticosteroid doses where possible. Physiologic replacement doses need no change; otherwise consider revaccination after therapy.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrocortisone
- Hydrocortisone + Mifepristone Contraindicated
- Hydrocortisone + Poliovirus vaccine live oral trivalent Contraindicated
- Hydrocortisone + Smallpox vaccine live Contraindicated
- Adenovirus types 4 and 7 live + Hydrocortisone Major
- Aldesleukin + Hydrocortisone Major
- Aspirin + Hydrocortisone Major
Frequently asked questions
Can I take Cholera vaccine with Hydrocortisone?
MediHelp rates the interaction as moderate. Cholera vaccine and Hydrocortisone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Immunosuppressive doses of corticosteroids can blunt the antibody response to vaccines. Oral cholera vaccine may therefore give weaker protection in patients on high-dose or prolonged hydrocortisone.
How serious is the interaction between Cholera vaccine and Hydrocortisone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Vaccinate before starting immunosuppressive corticosteroid doses where possible. Physiologic replacement doses need no change; otherwise consider revaccination after therapy.
What other medicines interact with Hydrocortisone?
MediHelp also lists interactions of Hydrocortisone with, for example, Mifepristone, Poliovirus vaccine live oral trivalent, Smallpox vaccine live. The full list is on the Hydrocortisone page.
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