Drug interactions
Cholera vaccine + Metronidazole
Severity: Moderate
Cholera vaccine and Metronidazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
The live attenuated oral cholera vaccine strain may be inhibited by systemic antibiotics, reducing colonization and the immune response. Metronidazole activity against the vaccine strain is limited, but labeling advises caution with systemic antibiotics.
What this interaction means in plain words
Cholera vaccine and Metronidazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Antibacterial activity may reduce replication of the live attenuated vaccine bacteria, impairing immunogenicity.
What to do
Avoid giving the oral cholera vaccine during antibiotic therapy and for the interval stated in labeling after the last antibiotic dose. Delay vaccination until antibiotics are completed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metronidazole
- Ethanol + Metronidazole Contraindicated
- Metronidazole + Pimozide Contraindicated
- Amiodarone + Metronidazole Major
- Disulfiram + Metronidazole Major
- Ergotamine + Metronidazole Major
- Lomitapide + Metronidazole Major
Frequently asked questions
Can I take Cholera vaccine with Metronidazole?
MediHelp rates the interaction as moderate. Cholera vaccine and Metronidazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. The live attenuated oral cholera vaccine strain may be inhibited by systemic antibiotics, reducing colonization and the immune response. Metronidazole activity against the vaccine strain is limited, but labeling advises caution with systemic antibiotics.
How serious is the interaction between Cholera vaccine and Metronidazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid giving the oral cholera vaccine during antibiotic therapy and for the interval stated in labeling after the last antibiotic dose. Delay vaccination until antibiotics are completed.
What other medicines interact with Metronidazole?
MediHelp also lists interactions of Metronidazole with, for example, Ethanol, Pimozide, Amiodarone. The full list is on the Metronidazole page.
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