Drug interactions
Cholera vaccine + Minocycline
Severity: Major
Cholera vaccine and Minocycline: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
The oral live attenuated cholera vaccine relies on the vaccine strain colonising the gut, and antibiotics active against it can reduce the immune response. Minocycline may therefore make the vaccine less effective.
What this interaction means in plain words
Cholera vaccine and Minocycline can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Antibacterial activity against the live attenuated Vibrio cholerae vaccine strain reduces colonisation and immunogenicity.
What to do
Do not give the vaccine to patients who have received systemic antibiotics in the preceding 14 days, and avoid antibiotics for a period after vaccination per labeling. Delay vaccination if needed.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Minocycline
- Acitretin + Minocycline Contraindicated
- Isotretinoin + Minocycline Contraindicated
- Methoxyflurane + Minocycline Major
- Minocycline + Palovarotene Major
- Minocycline + Pexidartinib Major
- Minocycline + Strontium ranelate Major
Frequently asked questions
Can I take Cholera vaccine with Minocycline?
MediHelp rates the interaction as major. Cholera vaccine and Minocycline can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. The oral live attenuated cholera vaccine relies on the vaccine strain colonising the gut, and antibiotics active against it can reduce the immune response. Minocycline may therefore make the vaccine less effective.
How serious is the interaction between Cholera vaccine and Minocycline?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not give the vaccine to patients who have received systemic antibiotics in the preceding 14 days, and avoid antibiotics for a period after vaccination per labeling. Delay vaccination if needed.
What other medicines interact with Minocycline?
MediHelp also lists interactions of Minocycline with, for example, Acitretin, Isotretinoin, Methoxyflurane. The full list is on the Minocycline page.
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