Drug interactions
Cholera vaccine + Thioguanine
Severity: Minor
Cholera vaccine and Thioguanine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Thioguanine suppresses bone marrow and immune function, which may weaken the antibody response to the cholera vaccine. Protection may be incomplete during treatment.
What this interaction means in plain words
Cholera vaccine and Thioguanine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Immunosuppression from the antimetabolite reduces vaccine response.
What to do
Where possible, vaccinate before starting thioguanine or during a treatment-free interval, and do not assume full protection during therapy.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Thioguanine
Frequently asked questions
Can I take Cholera vaccine with Thioguanine?
MediHelp rates the interaction as minor. Cholera vaccine and Thioguanine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Thioguanine suppresses bone marrow and immune function, which may weaken the antibody response to the cholera vaccine. Protection may be incomplete during treatment.
How serious is the interaction between Cholera vaccine and Thioguanine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Where possible, vaccinate before starting thioguanine or during a treatment-free interval, and do not assume full protection during therapy.
What other medicines interact with Thioguanine?
MediHelp also lists interactions of Thioguanine with, for example, Adenovirus types 4 and 7 live, Axicabtagene ciloleucel, Belatacept. The full list is on the Thioguanine page.
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