Drug interactions
Cholic acid + Glimepiride-pioglitazone
Severity: Moderate
Cholic acid and Glimepiride-pioglitazone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Glimepiride and pioglitazone may inhibit the bile salt export pump (BSEP). This could let conjugated bile salts build up in hepatocytes and cause liver injury in patients receiving cholic acid.
What this interaction means in plain words
Cholic acid and Glimepiride-pioglitazone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cholic acid belongs to Gastrointestinal Tract; Glimepiride-pioglitazone belongs to Endocrine.
Why it happens
Inhibition of the hepatic bile salt export pump reduces bile acid elimination from hepatocytes.
What to do
Avoid the combination where possible. If it is required, monitor serum transaminases and bilirubin and stop the offending drug if liver tests worsen.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Cholic acid and Glimepiride-pioglitazone, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Glimepiride-pioglitazone
Other interactions of Cholic acid
Frequently asked questions
Can I take Cholic acid with Glimepiride-pioglitazone?
MediHelp rates the interaction as moderate. Cholic acid and Glimepiride-pioglitazone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Glimepiride and pioglitazone may inhibit the bile salt export pump (BSEP). This could let conjugated bile salts build up in hepatocytes and cause liver injury in patients receiving cholic acid.
How serious is the interaction between Cholic acid and Glimepiride-pioglitazone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible. If it is required, monitor serum transaminases and bilirubin and stop the offending drug if liver tests worsen.
What other medicines interact with Glimepiride-pioglitazone?
MediHelp also lists interactions of Glimepiride-pioglitazone with, for example, Fluconazole, Gemfibrozil, Insulin aspart. The full list is on the Glimepiride-pioglitazone page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
