Drug interactions
Cholic acid + Pitavastatin
Severity: Moderate
Cholic acid and Pitavastatin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pitavastatin may inhibit bile salt export and lead to accumulation of conjugated bile salts in hepatocytes when given with cholic acid. This could cause liver injury or cholestatic symptoms.
What this interaction means in plain words
Cholic acid and Pitavastatin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cholic acid belongs to Gastrointestinal Tract; Pitavastatin belongs to Cardiovascular.
Why it happens
Inhibition of the bile salt export pump (BSEP) reduces biliary elimination of bile acids.
What to do
Avoid the combination if possible. If needed, monitor serum transaminases and bilirubin regularly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Pitavastatin
Other interactions of Cholic acid
Frequently asked questions
Can I take Cholic acid with Pitavastatin?
MediHelp rates the interaction as moderate. Cholic acid and Pitavastatin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Pitavastatin may inhibit bile salt export and lead to accumulation of conjugated bile salts in hepatocytes when given with cholic acid. This could cause liver injury or cholestatic symptoms.
How serious is the interaction between Cholic acid and Pitavastatin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination if possible. If needed, monitor serum transaminases and bilirubin regularly.
What other medicines interact with Pitavastatin?
MediHelp also lists interactions of Pitavastatin with, for example, Cyclosporin, Erythromycin base, Erythromycin ethylsuccinate. The full list is on the Pitavastatin page.
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