Drug interactions
Choline magnesium trisalicylate + Citalopram
Severity: Moderate
Choline magnesium trisalicylate and Citalopram: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
SSRIs impair platelet serotonin uptake and salicylates inhibit platelet function and irritate the gastric mucosa. Combined use raises the risk of gastrointestinal and other bleeding.
What this interaction means in plain words
Choline magnesium trisalicylate and Citalopram can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive impairment of platelet aggregation (SSRI serotonin depletion plus salicylate COX inhibition) with mucosal injury from salicylate.
What to do
Avoid the combination where possible, or use the lowest effective salicylate dose for the shortest time. Monitor for signs of bleeding and consider gastroprotection in at-risk patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Citalopram
- Cisapride + Citalopram Contraindicated
- Citalopram + Dronedarone Contraindicated
- Citalopram + Escitalopram Contraindicated
- Citalopram + Isocarboxazid Contraindicated
- Citalopram + Methylene blue Contraindicated
- Citalopram + Phenelzine Contraindicated
Frequently asked questions
Can I take Choline magnesium trisalicylate with Citalopram?
MediHelp rates the interaction as moderate. Choline magnesium trisalicylate and Citalopram can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. SSRIs impair platelet serotonin uptake and salicylates inhibit platelet function and irritate the gastric mucosa. Combined use raises the risk of gastrointestinal and other bleeding.
How serious is the interaction between Choline magnesium trisalicylate and Citalopram?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible, or use the lowest effective salicylate dose for the shortest time. Monitor for signs of bleeding and consider gastroprotection in at-risk patients.
What other medicines interact with Citalopram?
MediHelp also lists interactions of Citalopram with, for example, Cisapride, Dronedarone, Escitalopram. The full list is on the Citalopram page.
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