Drug interactions
Choline magnesium trisalicylate + Enalapril
Severity: Moderate
Choline magnesium trisalicylate and Enalapril: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
This non-acetylated salicylate has a lower effect on prostaglandin synthesis than classic NSAIDs but may still modestly reduce enalapril efficacy and affect renal function in at-risk patients. The risk is greatest with high doses, dehydration or existing kidney disease.
What this interaction means in plain words
Choline magnesium trisalicylate and Enalapril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Salicylate-mediated inhibition of renal prostaglandin synthesis can reduce renal perfusion and oppose ACE inhibitor effects.
What to do
Monitor blood pressure, serum creatinine and potassium when the combination is used, especially in elderly or volume-depleted patients. Use the lowest effective salicylate dose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Enalapril
- Aliskiren + Enalapril Contraindicated
- Enalapril + Protein a column Contraindicated
- Enalapril + Sacubitril / valsartan Contraindicated
- Enalapril + Sacubitril-valsartan Contraindicated
- Amifostine + Enalapril Major
- Amiloride + Enalapril Major
Frequently asked questions
Can I take Choline magnesium trisalicylate with Enalapril?
MediHelp rates the interaction as moderate. Choline magnesium trisalicylate and Enalapril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. This non-acetylated salicylate has a lower effect on prostaglandin synthesis than classic NSAIDs but may still modestly reduce enalapril efficacy and affect renal function in at-risk patients. The risk is greatest with high doses, dehydration or existing kidney disease.
How serious is the interaction between Choline magnesium trisalicylate and Enalapril?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, serum creatinine and potassium when the combination is used, especially in elderly or volume-depleted patients. Use the lowest effective salicylate dose.
What other medicines interact with Enalapril?
MediHelp also lists interactions of Enalapril with, for example, Aliskiren, Protein a column, Sacubitril / valsartan. The full list is on the Enalapril page.
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