Drug interactions
Choline magnesium trisalicylate + Escitalopram
Severity: Moderate
Choline magnesium trisalicylate and Escitalopram: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Salicylates inhibit platelet function and can irritate the gastric mucosa, and with an SSRI the combined bleeding risk is increased. Nonacetylated salicylates have weaker antiplatelet effect than aspirin, so the risk is somewhat lower.
What this interaction means in plain words
Choline magnesium trisalicylate and Escitalopram can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
SSRI-related platelet serotonin depletion combined with salicylate effects on platelets and gastric mucosa.
What to do
Monitor for GI bleeding, and consider gastroprotection in at-risk patients. Use the lowest effective salicylate dose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Escitalopram
- Cisapride + Escitalopram Contraindicated
- Citalopram + Escitalopram Contraindicated
- Escitalopram + Isocarboxazid Contraindicated
- Escitalopram + Methylene blue Contraindicated
- Escitalopram + Phenelzine Contraindicated
- Escitalopram + Pimozide Contraindicated
Frequently asked questions
Can I take Choline magnesium trisalicylate with Escitalopram?
MediHelp rates the interaction as moderate. Choline magnesium trisalicylate and Escitalopram can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Salicylates inhibit platelet function and can irritate the gastric mucosa, and with an SSRI the combined bleeding risk is increased. Nonacetylated salicylates have weaker antiplatelet effect than aspirin, so the risk is somewhat lower.
How serious is the interaction between Choline magnesium trisalicylate and Escitalopram?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for GI bleeding, and consider gastroprotection in at-risk patients. Use the lowest effective salicylate dose.
What other medicines interact with Escitalopram?
MediHelp also lists interactions of Escitalopram with, for example, Cisapride, Citalopram, Isocarboxazid. The full list is on the Escitalopram page.
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