Drug interactions
Choline magnesium trisalicylate + Fenoprofen
Severity: Moderate
Choline magnesium trisalicylate and Fenoprofen: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining two NSAIDs adds gastrointestinal and bleeding risk without added analgesic benefit. Salicylate also impairs platelet function irreversibly in a way that adds to fenoprofen's effect, and both can affect renal function. Salicylate may also lower fenoprofen exposure through protein-binding displacement or other effects.
What this interaction means in plain words
Choline magnesium trisalicylate and Fenoprofen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive inhibition of cyclooxygenase leading to reduced platelet function, gastric mucosal injury and renal prostaglandin suppression.
What to do
Avoid routine concurrent use of two NSAIDs; choose one agent. If combined, monitor for GI bleeding, hemoglobin and renal function.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fenoprofen
- Fenoprofen + Ketorolac Contraindicated
- Fenoprofen + Ketorolac intranasal Contraindicated
- Aceclofenac + Fenoprofen Major
- Acemetacin + Fenoprofen Major
- Acetylsalicylic acid + Fenoprofen Major
- Alteplase + Fenoprofen Major
Frequently asked questions
Can I take Choline magnesium trisalicylate with Fenoprofen?
MediHelp rates the interaction as moderate. Choline magnesium trisalicylate and Fenoprofen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Combining two NSAIDs adds gastrointestinal and bleeding risk without added analgesic benefit. Salicylate also impairs platelet function irreversibly in a way that adds to fenoprofen's effect, and both can affect renal function. Salicylate may also lower fenoprofen exposure through protein-binding displacement or other effects.
How serious is the interaction between Choline magnesium trisalicylate and Fenoprofen?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid routine concurrent use of two NSAIDs; choose one agent. If combined, monitor for GI bleeding, hemoglobin and renal function.
What other medicines interact with Fenoprofen?
MediHelp also lists interactions of Fenoprofen with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Fenoprofen page.
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