Drug interactions
Choline magnesium trisalicylate + Glibenclamide
Severity: Moderate
Choline magnesium trisalicylate and Glibenclamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Salicylates at anti-inflammatory doses can lower blood glucose and enhance sulfonylurea effect, risking hypoglycemia.
What this interaction means in plain words
Choline magnesium trisalicylate and Glibenclamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Salicylates increase insulin secretion, decrease hepatic glucose output, and may displace sulfonylureas from protein binding.
What to do
Monitor blood glucose when starting or stopping the salicylate and reduce the glyburide dose if needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glibenclamide
- Bosentan + Glibenclamide Contraindicated
- Cholic acid + Glibenclamide Major
- Ciprofloxacin + Glibenclamide Major
- Clarithromycin + Glibenclamide Major
- Fluconazole + Glibenclamide Major
- Glibenclamide + Insulin degludec-liraglutide Major
Frequently asked questions
Can I take Choline magnesium trisalicylate with Glibenclamide?
MediHelp rates the interaction as moderate. Choline magnesium trisalicylate and Glibenclamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Salicylates at anti-inflammatory doses can lower blood glucose and enhance sulfonylurea effect, risking hypoglycemia.
How serious is the interaction between Choline magnesium trisalicylate and Glibenclamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when starting or stopping the salicylate and reduce the glyburide dose if needed.
What other medicines interact with Glibenclamide?
MediHelp also lists interactions of Glibenclamide with, for example, Bosentan, Cholic acid, Ciprofloxacin. The full list is on the Glibenclamide page.
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