Drug interactions
Choline magnesium trisalicylate + Heparin
Severity: Moderate
Choline magnesium trisalicylate and Heparin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Choline magnesium trisalicylate is a non-acetylated salicylate with weak antiplatelet action, but salicylates at higher doses can still increase bleeding risk with heparin. The effect is generally smaller than with aspirin or other NSAIDs.
What this interaction means in plain words
Choline magnesium trisalicylate and Heparin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Salicylate may modestly impair platelet function and cause mucosal injury, adding to heparin's anticoagulant effect.
What to do
Monitor for signs of bleeding and hemoglobin, and use the lowest effective salicylate dose. Consider paracetamol as an alternative.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Heparin
- Defibrotide + Heparin Contraindicated
- Heparin + Ketorolac Contraindicated
- Heparin + Oritavancin Contraindicated
- Acemetacin + Heparin Major
- Acetylsalicylic acid + Heparin Major
- Alteplase + Heparin Major
Frequently asked questions
Can I take Choline magnesium trisalicylate with Heparin?
MediHelp rates the interaction as moderate. Choline magnesium trisalicylate and Heparin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Choline magnesium trisalicylate is a non-acetylated salicylate with weak antiplatelet action, but salicylates at higher doses can still increase bleeding risk with heparin. The effect is generally smaller than with aspirin or other NSAIDs.
How serious is the interaction between Choline magnesium trisalicylate and Heparin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for signs of bleeding and hemoglobin, and use the lowest effective salicylate dose. Consider paracetamol as an alternative.
What other medicines interact with Heparin?
MediHelp also lists interactions of Heparin with, for example, Defibrotide, Ketorolac, Oritavancin. The full list is on the Heparin page.
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