Drug interactions
Choline magnesium trisalicylate + Hydrocortisone
Severity: Moderate
Choline magnesium trisalicylate and Hydrocortisone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can damage the gastric mucosa, so combined use raises the risk of ulceration and gastrointestinal bleeding. Corticosteroids may also lower serum salicylate levels, which can rise again when the steroid is stopped.
What this interaction means in plain words
Choline magnesium trisalicylate and Hydrocortisone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive gastrointestinal mucosal injury; corticosteroids also increase renal clearance of salicylate.
What to do
Consider gastroprotection with a proton pump inhibitor in patients at risk and monitor for gastrointestinal bleeding. Check salicylate levels or effect when the corticosteroid dose is changed or stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Choline magnesium trisalicylate and Hydrocortisone, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Hydrocortisone
- Hydrocortisone + Mifepristone Contraindicated
- Hydrocortisone + Poliovirus vaccine live oral trivalent Contraindicated
- Hydrocortisone + Smallpox vaccine live Contraindicated
- Adenovirus types 4 and 7 live + Hydrocortisone Major
- Aldesleukin + Hydrocortisone Major
- Aspirin + Hydrocortisone Major
Frequently asked questions
Can I take Choline magnesium trisalicylate with Hydrocortisone?
MediHelp rates the interaction as moderate. Choline magnesium trisalicylate and Hydrocortisone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can damage the gastric mucosa, so combined use raises the risk of ulceration and gastrointestinal bleeding. Corticosteroids may also lower serum salicylate levels, which can rise again when the steroid is stopped.
How serious is the interaction between Choline magnesium trisalicylate and Hydrocortisone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider gastroprotection with a proton pump inhibitor in patients at risk and monitor for gastrointestinal bleeding. Check salicylate levels or effect when the corticosteroid dose is changed or stopped.
What other medicines interact with Hydrocortisone?
MediHelp also lists interactions of Hydrocortisone with, for example, Mifepristone, Poliovirus vaccine live oral trivalent, Smallpox vaccine live. The full list is on the Hydrocortisone page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
