Drug interactions
Choline magnesium trisalicylate + Indapamide
Severity: Moderate
Choline magnesium trisalicylate and Indapamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Salicylates at anti-inflammatory doses can reduce renal prostaglandin synthesis, which may blunt the diuretic and antihypertensive effect of indapamide and impair renal function, especially in dehydrated or elderly patients.
What this interaction means in plain words
Choline magnesium trisalicylate and Indapamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Salicylate inhibition of prostaglandin synthesis causes sodium and fluid retention and reduced renal perfusion, opposing the diuretic.
What to do
Monitor blood pressure, renal function and electrolytes, and ensure adequate hydration. Use the lowest effective salicylate dose or choose paracetamol.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Indapamide
Frequently asked questions
Can I take Choline magnesium trisalicylate with Indapamide?
MediHelp rates the interaction as moderate. Choline magnesium trisalicylate and Indapamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Salicylates at anti-inflammatory doses can reduce renal prostaglandin synthesis, which may blunt the diuretic and antihypertensive effect of indapamide and impair renal function, especially in dehydrated or elderly patients.
How serious is the interaction between Choline magnesium trisalicylate and Indapamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, renal function and electrolytes, and ensure adequate hydration. Use the lowest effective salicylate dose or choose paracetamol.
What other medicines interact with Indapamide?
MediHelp also lists interactions of Indapamide with, for example, Adagrasib, Amifostine, Amiodarone. The full list is on the Indapamide page.
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