Drug interactions
Choline magnesium trisalicylate + Ketorolac
Severity: Contraindicated
Choline magnesium trisalicylate and Ketorolac: contraindicated interaction.
Last updated Sources: Health Canada product monograph
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ketorolac is contraindicated with aspirin and NSAIDs, and non-acetylated salicylates add gastrointestinal and renal risk. Trisalicylate has less platelet effect than aspirin but still adds to ulcer and kidney injury risk when combined with ketorolac.
What this interaction means in plain words
Choline magnesium trisalicylate and Ketorolac are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Why it happens
Additive prostaglandin inhibition with GI mucosal injury and reduced renal blood flow, plus ketorolac's platelet inhibition.
What to do
Avoid combined use. Use one agent, or switch to a non-NSAID analgesic such as paracetamol.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Choline magnesium trisalicylate and Ketorolac, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
References
Other interactions of Ketorolac
- Aceclofenac + Ketorolac Contraindicated
- Acemetacin + Ketorolac Contraindicated
- Acetylsalicylic acid + Ketorolac Contraindicated
- Apixaban + Ketorolac Contraindicated
- Argatroban + Ketorolac Contraindicated
- Aspirin / citric acid / sodium bicarbonate + Ketorolac Contraindicated
Frequently asked questions
Can I take Choline magnesium trisalicylate with Ketorolac?
MediHelp rates the interaction as contraindicated. Choline magnesium trisalicylate and Ketorolac are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Ketorolac is contraindicated with aspirin and NSAIDs, and non-acetylated salicylates add gastrointestinal and renal risk. Trisalicylate has less platelet effect than aspirin but still adds to ulcer and kidney injury risk when combined with ketorolac.
How serious is the interaction between Choline magnesium trisalicylate and Ketorolac?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combined use. Use one agent, or switch to a non-NSAID analgesic such as paracetamol.
What other medicines interact with Ketorolac?
MediHelp also lists interactions of Ketorolac with, for example, Aceclofenac, Acemetacin, Acetylsalicylic acid. The full list is on the Ketorolac page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
