Drug interactions
Choline magnesium trisalicylate + Olmesartan
Severity: Moderate
Choline magnesium trisalicylate and Olmesartan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Salicylates at anti-inflammatory doses can blunt the blood pressure lowering effect of olmesartan. Together they may also impair renal function, particularly in elderly, volume-depleted or renally impaired patients, and may raise serum potassium.
What this interaction means in plain words
Choline magnesium trisalicylate and Olmesartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Inhibition of renal vasodilatory prostaglandins reduces glomerular perfusion and counteracts angiotensin receptor blockade, and this adds to the effect of ARB-related efferent arteriolar dilation on filtration.
What to do
Monitor blood pressure, serum creatinine and potassium after starting or changing salicylate dose, and ensure adequate hydration. Use the lowest effective salicylate dose for the shortest time or consider paracetamol instead.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Olmesartan
- Aliskiren + Olmesartan Contraindicated
- Olmesartan + Sparsentan Contraindicated
- Aldesleukin + Olmesartan Major
- Amifostine + Olmesartan Major
- Amiloride + Olmesartan Major
- Amlodipine-benazepril + Olmesartan Major
Frequently asked questions
Can I take Choline magnesium trisalicylate with Olmesartan?
MediHelp rates the interaction as moderate. Choline magnesium trisalicylate and Olmesartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Salicylates at anti-inflammatory doses can blunt the blood pressure lowering effect of olmesartan. Together they may also impair renal function, particularly in elderly, volume-depleted or renally impaired patients, and may raise serum potassium.
How serious is the interaction between Choline magnesium trisalicylate and Olmesartan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, serum creatinine and potassium after starting or changing salicylate dose, and ensure adequate hydration. Use the lowest effective salicylate dose for the shortest time or consider paracetamol instead.
What other medicines interact with Olmesartan?
MediHelp also lists interactions of Olmesartan with, for example, Aliskiren, Sparsentan, Aldesleukin. The full list is on the Olmesartan page.
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