Drug interactions
Choline magnesium trisalicylate + Telmisartan-amlodipine
Severity: Moderate
Choline magnesium trisalicylate and Telmisartan-amlodipine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Salicylates at anti-inflammatory doses can diminish telmisartan's blood pressure effect and impair renal function, especially in elderly or volume-depleted patients. Non-acetylated salicylates have less prostaglandin inhibition than other NSAIDs, so the effect may be smaller.
What this interaction means in plain words
Choline magnesium trisalicylate and Telmisartan-amlodipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Reduced renal prostaglandin synthesis leading to sodium retention and decreased glomerular perfusion alongside angiotensin receptor blockade.
What to do
Monitor blood pressure, creatinine and potassium during regular salicylate use and ensure adequate hydration.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Telmisartan-amlodipine
- Aliskiren + Telmisartan-amlodipine Contraindicated
- Sparsentan + Telmisartan-amlodipine Contraindicated
- Amifostine + Telmisartan-amlodipine Major
- Amiloride + Telmisartan-amlodipine Major
- Benazepril + Telmisartan-amlodipine Major
- Candesartan + Telmisartan-amlodipine Major
Frequently asked questions
Can I take Choline magnesium trisalicylate with Telmisartan-amlodipine?
MediHelp rates the interaction as moderate. Choline magnesium trisalicylate and Telmisartan-amlodipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Salicylates at anti-inflammatory doses can diminish telmisartan's blood pressure effect and impair renal function, especially in elderly or volume-depleted patients. Non-acetylated salicylates have less prostaglandin inhibition than other NSAIDs, so the effect may be smaller.
How serious is the interaction between Choline magnesium trisalicylate and Telmisartan-amlodipine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, creatinine and potassium during regular salicylate use and ensure adequate hydration.
What other medicines interact with Telmisartan-amlodipine?
MediHelp also lists interactions of Telmisartan-amlodipine with, for example, Aliskiren, Sparsentan, Amifostine. The full list is on the Telmisartan-amlodipine page.
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