Drug interactions
Ciprofibrate + Insulin detemir
Severity: Moderate
Ciprofibrate and Insulin detemir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fibrates may improve insulin sensitivity and enhance the glucose-lowering effect of insulin, occasionally causing hypoglycemia. The risk may be higher in patients with low albumin.
What this interaction means in plain words
Ciprofibrate and Insulin detemir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Fibrates activate PPAR-alpha, which may improve insulin sensitivity and add to insulin's glucose-lowering effect.
What to do
Monitor blood glucose when ciprofibrate is started or stopped. Reduce the insulin dose if hypoglycemia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Insulin detemir
Frequently asked questions
Can I take Ciprofibrate with Insulin detemir?
MediHelp rates the interaction as moderate. Ciprofibrate and Insulin detemir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fibrates may improve insulin sensitivity and enhance the glucose-lowering effect of insulin, occasionally causing hypoglycemia. The risk may be higher in patients with low albumin.
How serious is the interaction between Ciprofibrate and Insulin detemir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when ciprofibrate is started or stopped. Reduce the insulin dose if hypoglycemia occurs.
What other medicines interact with Insulin detemir?
MediHelp also lists interactions of Insulin detemir with, for example, Alogliptin-pioglitazone, Ethanol, Glimepiride-pioglitazone. The full list is on the Insulin detemir page.
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