Drug interactions
Citalopram + Conivaptan
Severity: Moderate
Citalopram and Conivaptan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Conivaptan is a CYP3A4 inhibitor and may modestly increase citalopram concentrations. This could increase dose-related adverse effects including QT prolongation.
What this interaction means in plain words
Citalopram and Conivaptan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Conivaptan inhibits CYP3A4, one of the pathways metabolizing citalopram.
What to do
Monitor for citalopram adverse effects during the short course of conivaptan, and consider an ECG in patients with QT risk factors. Correct electrolyte abnormalities.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Citalopram
- Cisapride + Citalopram Contraindicated
- Citalopram + Dronedarone Contraindicated
- Citalopram + Escitalopram Contraindicated
- Citalopram + Isocarboxazid Contraindicated
- Citalopram + Methylene blue Contraindicated
- Citalopram + Phenelzine Contraindicated
Frequently asked questions
Can I take Citalopram with Conivaptan?
MediHelp rates the interaction as moderate. Citalopram and Conivaptan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Conivaptan is a CYP3A4 inhibitor and may modestly increase citalopram concentrations. This could increase dose-related adverse effects including QT prolongation.
How serious is the interaction between Citalopram and Conivaptan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for citalopram adverse effects during the short course of conivaptan, and consider an ECG in patients with QT risk factors. Correct electrolyte abnormalities.
What other medicines interact with Citalopram?
MediHelp also lists interactions of Citalopram with, for example, Cisapride, Dronedarone, Escitalopram. The full list is on the Citalopram page.
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