Drug interactions
Citalopram + Dabigatran
Severity: Moderate
Citalopram and Dabigatran: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
SSRIs impair platelet function and, combined with an anticoagulant, increase the risk of bleeding. Gastrointestinal and intracranial bleeds are of most concern.
What this interaction means in plain words
Citalopram and Dabigatran can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive hemostatic impairment: SSRI-induced platelet serotonin depletion plus thrombin inhibition by dabigatran.
What to do
Monitor for bleeding and check hemoglobin periodically, and review other bleeding risk factors such as NSAIDs. Consider gastroprotection if risk is high.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Citalopram
- Cisapride + Citalopram Contraindicated
- Citalopram + Dronedarone Contraindicated
- Citalopram + Escitalopram Contraindicated
- Citalopram + Isocarboxazid Contraindicated
- Citalopram + Methylene blue Contraindicated
- Citalopram + Phenelzine Contraindicated
Frequently asked questions
Can I take Citalopram with Dabigatran?
MediHelp rates the interaction as moderate. Citalopram and Dabigatran can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. SSRIs impair platelet function and, combined with an anticoagulant, increase the risk of bleeding. Gastrointestinal and intracranial bleeds are of most concern.
How serious is the interaction between Citalopram and Dabigatran?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for bleeding and check hemoglobin periodically, and review other bleeding risk factors such as NSAIDs. Consider gastroprotection if risk is high.
What other medicines interact with Citalopram?
MediHelp also lists interactions of Citalopram with, for example, Cisapride, Dronedarone, Escitalopram. The full list is on the Citalopram page.
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