Drug interactions
Citalopram + Dabrafenib
Severity: Minor
Citalopram and Dabrafenib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dabrafenib induces CYP3A4 and other enzymes and may lower citalopram concentrations. Reduced antidepressant effect is possible, though the effect is probably modest because multiple enzymes metabolize citalopram.
What this interaction means in plain words
Citalopram and Dabrafenib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Citalopram belongs to Central Nervous System; Dabrafenib belongs to Oncology.
Why it happens
Dabrafenib induction of CYP3A4 (and CYP2C19) increases citalopram clearance.
What to do
Monitor for reduced antidepressant response and titrate citalopram within labeled limits if needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Citalopram
- Cisapride + Citalopram Contraindicated
- Citalopram + Dronedarone Contraindicated
- Citalopram + Escitalopram Contraindicated
- Citalopram + Isocarboxazid Contraindicated
- Citalopram + Methylene blue Contraindicated
- Citalopram + Phenelzine Contraindicated
Other interactions of Dabrafenib
Frequently asked questions
Can I take Citalopram with Dabrafenib?
MediHelp rates the interaction as minor. Citalopram and Dabrafenib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Dabrafenib induces CYP3A4 and other enzymes and may lower citalopram concentrations. Reduced antidepressant effect is possible, though the effect is probably modest because multiple enzymes metabolize citalopram.
How serious is the interaction between Citalopram and Dabrafenib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for reduced antidepressant response and titrate citalopram within labeled limits if needed.
What other medicines interact with Citalopram?
MediHelp also lists interactions of Citalopram with, for example, Cisapride, Dronedarone, Escitalopram. The full list is on the Citalopram page.
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