Drug interactions
Citalopram + Dextroamphetamine transdermal
Severity: Moderate
Citalopram and Dextroamphetamine transdermal: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amphetamines enhance serotonergic transmission and combining them with an SSRI can rarely cause serotonin syndrome. Features include agitation, tremor, hyperthermia, diarrhea and neuromuscular hyperactivity.
What this interaction means in plain words
Citalopram and Dextroamphetamine transdermal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive serotonergic effects through amphetamine-induced serotonin release and SSRI reuptake inhibition.
What to do
Start with low doses and monitor for serotonin syndrome, especially after dose increases. Stop both agents if it develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Citalopram
- Cisapride + Citalopram Contraindicated
- Citalopram + Dronedarone Contraindicated
- Citalopram + Escitalopram Contraindicated
- Citalopram + Isocarboxazid Contraindicated
- Citalopram + Methylene blue Contraindicated
- Citalopram + Phenelzine Contraindicated
Frequently asked questions
Can I take Citalopram with Dextroamphetamine transdermal?
MediHelp rates the interaction as moderate. Citalopram and Dextroamphetamine transdermal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Amphetamines enhance serotonergic transmission and combining them with an SSRI can rarely cause serotonin syndrome. Features include agitation, tremor, hyperthermia, diarrhea and neuromuscular hyperactivity.
How serious is the interaction between Citalopram and Dextroamphetamine transdermal?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start with low doses and monitor for serotonin syndrome, especially after dose increases. Stop both agents if it develops.
What other medicines interact with Citalopram?
MediHelp also lists interactions of Citalopram with, for example, Cisapride, Dronedarone, Escitalopram. The full list is on the Citalopram page.
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