Drug interactions
Citalopram + Diazepam intranasal
Severity: Moderate
Citalopram and Diazepam intranasal: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Benzodiazepines cause sedation and respiratory depression, and citalopram can add to drowsiness and psychomotor impairment. Diazepam levels may also rise slightly because citalopram weakly affects CYP2C19.
What this interaction means in plain words
Citalopram and Diazepam intranasal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression from pharmacodynamic synergism.
What to do
Monitor sedation and psychomotor function, and warn patients against driving or operating machinery. Use the lowest effective diazepam dose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Citalopram
- Cisapride + Citalopram Contraindicated
- Citalopram + Dronedarone Contraindicated
- Citalopram + Escitalopram Contraindicated
- Citalopram + Isocarboxazid Contraindicated
- Citalopram + Methylene blue Contraindicated
- Citalopram + Phenelzine Contraindicated
Frequently asked questions
Can I take Citalopram with Diazepam intranasal?
MediHelp rates the interaction as moderate. Citalopram and Diazepam intranasal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Benzodiazepines cause sedation and respiratory depression, and citalopram can add to drowsiness and psychomotor impairment. Diazepam levels may also rise slightly because citalopram weakly affects CYP2C19.
How serious is the interaction between Citalopram and Diazepam intranasal?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation and psychomotor function, and warn patients against driving or operating machinery. Use the lowest effective diazepam dose.
What other medicines interact with Citalopram?
MediHelp also lists interactions of Citalopram with, for example, Cisapride, Dronedarone, Escitalopram. The full list is on the Citalopram page.
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