Drug interactions
Citalopram + Encorafenib
Severity: Major
Citalopram and Encorafenib: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Encorafenib causes dose-dependent QTc prolongation and citalopram also lengthens the QT interval. The combination increases the risk of torsades de pointes.
What this interaction means in plain words
Citalopram and Encorafenib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Citalopram belongs to Central Nervous System; Encorafenib belongs to Oncology.
Why it happens
Additive prolongation of cardiac repolarization.
What to do
Avoid if possible and choose an antidepressant with lower QT risk. If used, monitor ECG and electrolytes and apply labeled encorafenib dose reductions for QTc prolongation.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Citalopram
- Cisapride + Citalopram Contraindicated
- Citalopram + Dronedarone Contraindicated
- Citalopram + Escitalopram Contraindicated
- Citalopram + Isocarboxazid Contraindicated
- Citalopram + Methylene blue Contraindicated
- Citalopram + Phenelzine Contraindicated
Other interactions of Encorafenib
Frequently asked questions
Can I take Citalopram with Encorafenib?
MediHelp rates the interaction as major. Citalopram and Encorafenib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Encorafenib causes dose-dependent QTc prolongation and citalopram also lengthens the QT interval. The combination increases the risk of torsades de pointes.
How serious is the interaction between Citalopram and Encorafenib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible and choose an antidepressant with lower QT risk. If used, monitor ECG and electrolytes and apply labeled encorafenib dose reductions for QTc prolongation.
What other medicines interact with Citalopram?
MediHelp also lists interactions of Citalopram with, for example, Cisapride, Dronedarone, Escitalopram. The full list is on the Citalopram page.
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