Drug interactions
Citalopram + Fosamprenavir
Severity: Moderate
Citalopram and Fosamprenavir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fosamprenavir, whose active form amprenavir inhibits CYP3A4 (more so when boosted with ritonavir), may raise citalopram concentrations. This increases the potential for serotonergic effects and QT prolongation.
What this interaction means in plain words
Citalopram and Fosamprenavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Inhibition of CYP3A4-mediated citalopram metabolism by amprenavir.
What to do
Titrate citalopram from the lowest dose and monitor response and tolerability. Check an ECG if other QT-prolonging factors exist.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Citalopram
- Cisapride + Citalopram Contraindicated
- Citalopram + Dronedarone Contraindicated
- Citalopram + Escitalopram Contraindicated
- Citalopram + Isocarboxazid Contraindicated
- Citalopram + Methylene blue Contraindicated
- Citalopram + Phenelzine Contraindicated
Frequently asked questions
Can I take Citalopram with Fosamprenavir?
MediHelp rates the interaction as moderate. Citalopram and Fosamprenavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fosamprenavir, whose active form amprenavir inhibits CYP3A4 (more so when boosted with ritonavir), may raise citalopram concentrations. This increases the potential for serotonergic effects and QT prolongation.
How serious is the interaction between Citalopram and Fosamprenavir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Titrate citalopram from the lowest dose and monitor response and tolerability. Check an ECG if other QT-prolonging factors exist.
What other medicines interact with Citalopram?
MediHelp also lists interactions of Citalopram with, for example, Cisapride, Dronedarone, Escitalopram. The full list is on the Citalopram page.
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