Drug interactions
Citalopram + Ioflupane i
Severity: Moderate
Citalopram and Ioflupane i: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Serotonin reuptake inhibitors can alter striatal binding of ioflupane I-123 and potentially affect image interpretation of DaTscan. The effect is mainly on the serotonin transporter signal in non-striatal regions, and clinical impact is uncertain.
What this interaction means in plain words
Citalopram and Ioflupane i can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Competition for transporter binding sites (serotonin transporter) that may alter tracer uptake.
What to do
Tell the nuclear medicine team about the SSRI before imaging. Consider whether citalopram can be paused before the scan only if clinically safe.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Citalopram
- Cisapride + Citalopram Contraindicated
- Citalopram + Dronedarone Contraindicated
- Citalopram + Escitalopram Contraindicated
- Citalopram + Isocarboxazid Contraindicated
- Citalopram + Methylene blue Contraindicated
- Citalopram + Phenelzine Contraindicated
Frequently asked questions
Can I take Citalopram with Ioflupane i?
MediHelp rates the interaction as moderate. Citalopram and Ioflupane i can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Serotonin reuptake inhibitors can alter striatal binding of ioflupane I-123 and potentially affect image interpretation of DaTscan. The effect is mainly on the serotonin transporter signal in non-striatal regions, and clinical impact is uncertain.
How serious is the interaction between Citalopram and Ioflupane i?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Tell the nuclear medicine team about the SSRI before imaging. Consider whether citalopram can be paused before the scan only if clinically safe.
What other medicines interact with Citalopram?
MediHelp also lists interactions of Citalopram with, for example, Cisapride, Dronedarone, Escitalopram. The full list is on the Citalopram page.
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