Drug interactions
Citalopram + Lorcaserin
Severity: Major
Citalopram and Lorcaserin: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lorcaserin is a serotonin 5-HT2C agonist, and using it with an SSRI may increase the risk of serotonin syndrome. It has been withdrawn from many markets, so this is mainly relevant to older records.
What this interaction means in plain words
Citalopram and Lorcaserin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive serotonergic effects from 5-HT2C agonism and serotonin reuptake inhibition.
What to do
Avoid the combination or monitor closely for serotonin syndrome symptoms. Stop lorcaserin if signs of toxicity appear.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Citalopram
- Cisapride + Citalopram Contraindicated
- Citalopram + Dronedarone Contraindicated
- Citalopram + Escitalopram Contraindicated
- Citalopram + Isocarboxazid Contraindicated
- Citalopram + Methylene blue Contraindicated
- Citalopram + Phenelzine Contraindicated
Frequently asked questions
Can I take Citalopram with Lorcaserin?
MediHelp rates the interaction as major. Citalopram and Lorcaserin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Lorcaserin is a serotonin 5-HT2C agonist, and using it with an SSRI may increase the risk of serotonin syndrome. It has been withdrawn from many markets, so this is mainly relevant to older records.
How serious is the interaction between Citalopram and Lorcaserin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination or monitor closely for serotonin syndrome symptoms. Stop lorcaserin if signs of toxicity appear.
What other medicines interact with Citalopram?
MediHelp also lists interactions of Citalopram with, for example, Cisapride, Dronedarone, Escitalopram. The full list is on the Citalopram page.
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