Drug interactions
Citalopram + Methyclothiazide
Severity: Moderate
Citalopram and Methyclothiazide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can cause hyponatremia, and together the risk is higher, particularly in elderly patients. Symptoms include confusion, headache, falls and seizures.
What this interaction means in plain words
Citalopram and Methyclothiazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Thiazide-induced renal sodium loss combined with SSRI-associated SIADH.
What to do
Check serum sodium at baseline and within the first weeks of combined therapy, especially in older patients. Stop or change one drug if sodium falls significantly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Citalopram
- Cisapride + Citalopram Contraindicated
- Citalopram + Dronedarone Contraindicated
- Citalopram + Escitalopram Contraindicated
- Citalopram + Isocarboxazid Contraindicated
- Citalopram + Methylene blue Contraindicated
- Citalopram + Phenelzine Contraindicated
Frequently asked questions
Can I take Citalopram with Methyclothiazide?
MediHelp rates the interaction as moderate. Citalopram and Methyclothiazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can cause hyponatremia, and together the risk is higher, particularly in elderly patients. Symptoms include confusion, headache, falls and seizures.
How serious is the interaction between Citalopram and Methyclothiazide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check serum sodium at baseline and within the first weeks of combined therapy, especially in older patients. Stop or change one drug if sodium falls significantly.
What other medicines interact with Citalopram?
MediHelp also lists interactions of Citalopram with, for example, Cisapride, Dronedarone, Escitalopram. The full list is on the Citalopram page.
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