Drug interactions
Citalopram + Metoclopramide intranasal
Severity: Moderate
Citalopram and Metoclopramide intranasal: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Metoclopramide with an SSRI can increase the risk of extrapyramidal symptoms and serotonin syndrome or neuroleptic malignant syndrome-like reactions. Citalopram may also contribute to QT effects.
What this interaction means in plain words
Citalopram and Metoclopramide intranasal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive serotonergic and dopamine-related pharmacodynamic effects; metoclopramide is dopamine D2 antagonist.
What to do
Monitor for tremor, rigidity, agitation and other signs of serotonin toxicity or extrapyramidal effects. Consider an alternative antiemetic or prokinetic if symptoms occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Citalopram
- Cisapride + Citalopram Contraindicated
- Citalopram + Dronedarone Contraindicated
- Citalopram + Escitalopram Contraindicated
- Citalopram + Isocarboxazid Contraindicated
- Citalopram + Methylene blue Contraindicated
- Citalopram + Phenelzine Contraindicated
Frequently asked questions
Can I take Citalopram with Metoclopramide intranasal?
MediHelp rates the interaction as moderate. Citalopram and Metoclopramide intranasal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Metoclopramide with an SSRI can increase the risk of extrapyramidal symptoms and serotonin syndrome or neuroleptic malignant syndrome-like reactions. Citalopram may also contribute to QT effects.
How serious is the interaction between Citalopram and Metoclopramide intranasal?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for tremor, rigidity, agitation and other signs of serotonin toxicity or extrapyramidal effects. Consider an alternative antiemetic or prokinetic if symptoms occur.
What other medicines interact with Citalopram?
MediHelp also lists interactions of Citalopram with, for example, Cisapride, Dronedarone, Escitalopram. The full list is on the Citalopram page.
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