Drug interactions
Citalopram + Octreotide
Severity: Moderate
Citalopram and Octreotide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Octreotide can cause bradycardia and QT prolongation, which may add to the QT effect of citalopram. The risk is higher in patients with heart disease, electrolyte disturbances or other QT-prolonging drugs.
What this interaction means in plain words
Citalopram and Octreotide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Citalopram belongs to Central Nervous System; Octreotide belongs to Endocrine.
Why it happens
Additive QT prolongation, with octreotide-related bradycardia increasing proarrhythmic risk.
What to do
Check a baseline ECG and electrolytes and repeat if symptoms or risk factors appear. Correct potassium and magnesium abnormalities.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Citalopram
- Cisapride + Citalopram Contraindicated
- Citalopram + Dronedarone Contraindicated
- Citalopram + Escitalopram Contraindicated
- Citalopram + Isocarboxazid Contraindicated
- Citalopram + Methylene blue Contraindicated
- Citalopram + Phenelzine Contraindicated
Other interactions of Octreotide
Frequently asked questions
Can I take Citalopram with Octreotide?
MediHelp rates the interaction as moderate. Citalopram and Octreotide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Octreotide can cause bradycardia and QT prolongation, which may add to the QT effect of citalopram. The risk is higher in patients with heart disease, electrolyte disturbances or other QT-prolonging drugs.
How serious is the interaction between Citalopram and Octreotide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check a baseline ECG and electrolytes and repeat if symptoms or risk factors appear. Correct potassium and magnesium abnormalities.
What other medicines interact with Citalopram?
MediHelp also lists interactions of Citalopram with, for example, Cisapride, Dronedarone, Escitalopram. The full list is on the Citalopram page.
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