Drug interactions
Citalopram + Romidepsin
Severity: Major
Citalopram and Romidepsin: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Romidepsin can cause QT changes and ECG abnormalities, and citalopram adds dose-related QT prolongation. The combination may raise the risk of ventricular arrhythmia.
What this interaction means in plain words
Citalopram and Romidepsin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive prolongation of cardiac repolarization.
What to do
Monitor ECG and correct potassium and magnesium before and during romidepsin cycles. Consider an alternative antidepressant if QTc prolongs.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Citalopram
- Cisapride + Citalopram Contraindicated
- Citalopram + Dronedarone Contraindicated
- Citalopram + Escitalopram Contraindicated
- Citalopram + Isocarboxazid Contraindicated
- Citalopram + Methylene blue Contraindicated
- Citalopram + Phenelzine Contraindicated
Frequently asked questions
Can I take Citalopram with Romidepsin?
MediHelp rates the interaction as major. Citalopram and Romidepsin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Romidepsin can cause QT changes and ECG abnormalities, and citalopram adds dose-related QT prolongation. The combination may raise the risk of ventricular arrhythmia.
How serious is the interaction between Citalopram and Romidepsin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG and correct potassium and magnesium before and during romidepsin cycles. Consider an alternative antidepressant if QTc prolongs.
What other medicines interact with Citalopram?
MediHelp also lists interactions of Citalopram with, for example, Cisapride, Dronedarone, Escitalopram. The full list is on the Citalopram page.
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