Drug interactions
Citalopram + Sufentanil sl
Severity: Moderate
Citalopram and Sufentanil sl: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Opioids such as sufentanil have serotonergic activity and may cause serotonin syndrome with SSRIs. The combination also adds CNS and respiratory depression.
What this interaction means in plain words
Citalopram and Sufentanil sl can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive serotonergic activity and additive CNS depression.
What to do
Monitor for serotonin toxicity (clonus, agitation, hyperthermia, diarrhea) and sedation, especially at initiation and dose changes. Stop sufentanil or adjust therapy if symptoms occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Citalopram
- Cisapride + Citalopram Contraindicated
- Citalopram + Dronedarone Contraindicated
- Citalopram + Escitalopram Contraindicated
- Citalopram + Isocarboxazid Contraindicated
- Citalopram + Methylene blue Contraindicated
- Citalopram + Phenelzine Contraindicated
Frequently asked questions
Can I take Citalopram with Sufentanil sl?
MediHelp rates the interaction as moderate. Citalopram and Sufentanil sl can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Opioids such as sufentanil have serotonergic activity and may cause serotonin syndrome with SSRIs. The combination also adds CNS and respiratory depression.
How serious is the interaction between Citalopram and Sufentanil sl?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for serotonin toxicity (clonus, agitation, hyperthermia, diarrhea) and sedation, especially at initiation and dose changes. Stop sufentanil or adjust therapy if symptoms occur.
What other medicines interact with Citalopram?
MediHelp also lists interactions of Citalopram with, for example, Cisapride, Dronedarone, Escitalopram. The full list is on the Citalopram page.
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