Drug interactions
Citalopram + Umeclidinium bromide / vilanterol inhaled
Severity: Moderate
Citalopram and Umeclidinium bromide / vilanterol inhaled: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vilanterol, a long-acting beta-agonist, can affect cardiac repolarization and heart rate, and citalopram prolongs the QT interval. Systemic exposure from inhalation is low, so the clinical risk is modest but may matter in susceptible patients.
What this interaction means in plain words
Citalopram and Umeclidinium bromide / vilanterol inhaled can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive QTc prolongation and adrenergic cardiac effects.
What to do
Monitor for palpitations and arrhythmia, and obtain an ECG in patients with QT risk factors or on higher citalopram doses. Correct hypokalemia.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Citalopram
- Cisapride + Citalopram Contraindicated
- Citalopram + Dronedarone Contraindicated
- Citalopram + Escitalopram Contraindicated
- Citalopram + Isocarboxazid Contraindicated
- Citalopram + Methylene blue Contraindicated
- Citalopram + Phenelzine Contraindicated
Frequently asked questions
Can I take Citalopram with Umeclidinium bromide / vilanterol inhaled?
MediHelp rates the interaction as moderate. Citalopram and Umeclidinium bromide / vilanterol inhaled can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Vilanterol, a long-acting beta-agonist, can affect cardiac repolarization and heart rate, and citalopram prolongs the QT interval. Systemic exposure from inhalation is low, so the clinical risk is modest but may matter in susceptible patients.
How serious is the interaction between Citalopram and Umeclidinium bromide / vilanterol inhaled?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for palpitations and arrhythmia, and obtain an ECG in patients with QT risk factors or on higher citalopram doses. Correct hypokalemia.
What other medicines interact with Citalopram?
MediHelp also lists interactions of Citalopram with, for example, Cisapride, Dronedarone, Escitalopram. The full list is on the Citalopram page.
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