Drug interactions
Citalopram + Vorapaxar
Severity: Moderate
Citalopram and Vorapaxar: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vorapaxar is an antiplatelet agent and SSRIs impair platelet function, so combined use may increase bleeding risk including gastrointestinal bleeding. Vorapaxar is already associated with a high bleeding tendency.
What this interaction means in plain words
Citalopram and Vorapaxar can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive impairment of hemostasis: PAR-1 antagonism by vorapaxar plus SSRI-related depletion of platelet serotonin.
What to do
Monitor for signs of bleeding and consider gastroprotection in patients at higher GI risk. Reassess the need for both drugs if bleeding occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Citalopram
- Cisapride + Citalopram Contraindicated
- Citalopram + Dronedarone Contraindicated
- Citalopram + Escitalopram Contraindicated
- Citalopram + Isocarboxazid Contraindicated
- Citalopram + Methylene blue Contraindicated
- Citalopram + Phenelzine Contraindicated
Frequently asked questions
Can I take Citalopram with Vorapaxar?
MediHelp rates the interaction as moderate. Citalopram and Vorapaxar can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Vorapaxar is an antiplatelet agent and SSRIs impair platelet function, so combined use may increase bleeding risk including gastrointestinal bleeding. Vorapaxar is already associated with a high bleeding tendency.
How serious is the interaction between Citalopram and Vorapaxar?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for signs of bleeding and consider gastroprotection in patients at higher GI risk. Reassess the need for both drugs if bleeding occurs.
What other medicines interact with Citalopram?
MediHelp also lists interactions of Citalopram with, for example, Cisapride, Dronedarone, Escitalopram. The full list is on the Citalopram page.
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