Drug interactions
Cladribine + Influenza virus vaccine adjuvanted
Severity: Moderate
Cladribine and Influenza virus vaccine adjuvanted: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
The adjuvanted H5N1 vaccine is inactivated and safe to give, but cladribine-induced lymphopenia may reduce the immune response.
What this interaction means in plain words
Cladribine and Influenza virus vaccine adjuvanted can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Cladribine-related lymphocyte depletion reduces vaccine immunogenicity.
What to do
Vaccinate before starting cladribine where possible, ideally a few weeks earlier. If given during therapy, do not rely on the response alone for protection.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cladribine
- Adenovirus types 4 and 7 live + Cladribine Contraindicated
- Cladribine + Siponimod Contraindicated
- Cladribine + Tofacitinib Contraindicated
- Axicabtagene ciloleucel + Cladribine Major
- Belatacept + Cladribine Major
- Brexucabtagene autoleucel + Cladribine Major
Frequently asked questions
Can I take Cladribine with Influenza virus vaccine adjuvanted?
MediHelp rates the interaction as moderate. Cladribine and Influenza virus vaccine adjuvanted can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. The adjuvanted H5N1 vaccine is inactivated and safe to give, but cladribine-induced lymphopenia may reduce the immune response.
How serious is the interaction between Cladribine and Influenza virus vaccine adjuvanted?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Vaccinate before starting cladribine where possible, ideally a few weeks earlier. If given during therapy, do not rely on the response alone for protection.
What other medicines interact with Cladribine?
MediHelp also lists interactions of Cladribine with, for example, Adenovirus types 4 and 7 live, Siponimod, Tofacitinib. The full list is on the Cladribine page.
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