Drug interactions
Clemastine + Dextroamphetamine
Severity: Minor
Clemastine and Dextroamphetamine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Clemastine causes sedation that dextroamphetamine may partially counteract. The stimulant may mask drowsiness without fully restoring performance. Clinically important harm is unlikely.
What this interaction means in plain words
Clemastine and Dextroamphetamine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Clemastine belongs to Respiratory; Dextroamphetamine belongs to Central Nervous System.
Why it happens
Opposing central nervous system effects (H1 antagonism versus amphetamine-induced monoamine release).
What to do
No action beyond awareness is usually required. Counsel patients about residual impairment when driving.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Dextroamphetamine
- Dextroamphetamine + Isocarboxazid Contraindicated
- Dextroamphetamine + Linezolid Contraindicated
- Dextroamphetamine + Methylene blue Contraindicated
- Dextroamphetamine + Phenelzine Contraindicated
- Dextroamphetamine + Rasagiline Contraindicated
- Dextroamphetamine + Safinamide Contraindicated
Other interactions of Clemastine
Frequently asked questions
Can I take Clemastine with Dextroamphetamine?
MediHelp rates the interaction as minor. Clemastine and Dextroamphetamine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Clemastine causes sedation that dextroamphetamine may partially counteract. The stimulant may mask drowsiness without fully restoring performance. Clinically important harm is unlikely.
How serious is the interaction between Clemastine and Dextroamphetamine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No action beyond awareness is usually required. Counsel patients about residual impairment when driving.
What other medicines interact with Dextroamphetamine?
MediHelp also lists interactions of Dextroamphetamine with, for example, Isocarboxazid, Linezolid, Methylene blue. The full list is on the Dextroamphetamine page.
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