Drug interactions
Clemastine + Dipipanone
Severity: Moderate
Clemastine and Dipipanone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dipipanone is an opioid analgesic and clemastine is a sedating antihistamine. Combining them can deepen sedation and psychomotor impairment, and with higher opioid doses may contribute to respiratory depression.
What this interaction means in plain words
Clemastine and Dipipanone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive central nervous system depressant effects.
What to do
Start with low doses and monitor sedation and respiratory rate, especially in elderly or opioid-naive patients. Advise against driving and alcohol use.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clemastine
Frequently asked questions
Can I take Clemastine with Dipipanone?
MediHelp rates the interaction as moderate. Clemastine and Dipipanone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dipipanone is an opioid analgesic and clemastine is a sedating antihistamine. Combining them can deepen sedation and psychomotor impairment, and with higher opioid doses may contribute to respiratory depression.
How serious is the interaction between Clemastine and Dipipanone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start with low doses and monitor sedation and respiratory rate, especially in elderly or opioid-naive patients. Advise against driving and alcohol use.
What other medicines interact with Clemastine?
MediHelp also lists interactions of Clemastine with, for example, Alfentanil, Benzhydrocodone / acetaminophen, Buprenorphine buccal. The full list is on the Clemastine page.
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