Drug interactions
Clemastine + Droperidol
Severity: Moderate
Clemastine and Droperidol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Droperidol is a sedating neuroleptic and clemastine is a sedating antihistamine, so combined use can increase drowsiness and psychomotor impairment. Droperidol also prolongs the QT interval, and additive anticholinergic effects may add to the burden.
What this interaction means in plain words
Clemastine and Droperidol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive central nervous system depression and antimuscarinic effects.
What to do
Monitor sedation level and use the lowest effective droperidol dose. Check ECG and electrolytes if other QT-prolonging risk factors are present.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clemastine
Frequently asked questions
Can I take Clemastine with Droperidol?
MediHelp rates the interaction as moderate. Clemastine and Droperidol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Droperidol is a sedating neuroleptic and clemastine is a sedating antihistamine, so combined use can increase drowsiness and psychomotor impairment. Droperidol also prolongs the QT interval, and additive anticholinergic effects may add to the burden.
How serious is the interaction between Clemastine and Droperidol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation level and use the lowest effective droperidol dose. Check ECG and electrolytes if other QT-prolonging risk factors are present.
What other medicines interact with Clemastine?
MediHelp also lists interactions of Clemastine with, for example, Alfentanil, Benzhydrocodone / acetaminophen, Buprenorphine buccal. The full list is on the Clemastine page.
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