Drug interactions
Clemastine + Epinephrine
Severity: Minor
Clemastine and Epinephrine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Used together, clemastine and epinephrine are routine in the treatment of allergic reactions, and no clinically important adverse interaction is established. Epinephrine's stimulant effect may counter some antihistamine drowsiness, but this is not reliable.
What this interaction means in plain words
Clemastine and Epinephrine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Clemastine belongs to Respiratory; Epinephrine belongs to Endocrine.
Why it happens
Opposing CNS effects; no established pharmacokinetic or significant pharmacodynamic mechanism.
What to do
No dose change is needed. In anaphylaxis, give epinephrine first and treat the antihistamine as an adjunct only.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Clemastine
Other interactions of Epinephrine
- Epinephrine + Isocarboxazid Contraindicated
- Epinephrine + Phenelzine Contraindicated
- Epinephrine + Tranylcypromine Contraindicated
- Acebutolol + Epinephrine Major
- Amitriptyline + Epinephrine Major
- Amoxapine + Epinephrine Major
Frequently asked questions
Can I take Clemastine with Epinephrine?
MediHelp rates the interaction as minor. Clemastine and Epinephrine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Used together, clemastine and epinephrine are routine in the treatment of allergic reactions, and no clinically important adverse interaction is established. Epinephrine's stimulant effect may counter some antihistamine drowsiness, but this is not reliable.
How serious is the interaction between Clemastine and Epinephrine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is needed. In anaphylaxis, give epinephrine first and treat the antihistamine as an adjunct only.
What other medicines interact with Clemastine?
MediHelp also lists interactions of Clemastine with, for example, Alfentanil, Benzhydrocodone / acetaminophen, Buprenorphine buccal. The full list is on the Clemastine page.
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