Drug interactions
Clemastine + Esketamine
Severity: Moderate
Clemastine and Esketamine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Clemastine is a sedating first-generation antihistamine. With esketamine, drowsiness and psychomotor impairment may be greater than with either agent alone.
What this interaction means in plain words
Clemastine and Esketamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clemastine belongs to Respiratory; Esketamine belongs to Central Nervous System.
Why it happens
Additive CNS depression from esketamine and central H1 receptor antagonism.
What to do
Monitor sedation after esketamine administration. Prefer a non-sedating antihistamine where possible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Esketamine
Other interactions of Clemastine
Frequently asked questions
Can I take Clemastine with Esketamine?
MediHelp rates the interaction as moderate. Clemastine and Esketamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Clemastine is a sedating first-generation antihistamine. With esketamine, drowsiness and psychomotor impairment may be greater than with either agent alone.
How serious is the interaction between Clemastine and Esketamine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation after esketamine administration. Prefer a non-sedating antihistamine where possible.
What other medicines interact with Esketamine?
MediHelp also lists interactions of Esketamine with, for example, Alfentanil, Amobarbital, Belladonna and opium. The full list is on the Esketamine page.
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