Drug interactions
Clemastine + Estazolam
Severity: Moderate
Clemastine and Estazolam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Estazolam is a benzodiazepine hypnotic and clemastine is a sedating antihistamine. Together they can produce greater drowsiness, dizziness, impaired coordination and next-day impairment, with increased fall risk in older patients.
What this interaction means in plain words
Clemastine and Estazolam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive central nervous system depression via GABA-A enhancement and H1 receptor blockade.
What to do
Use the lowest effective doses and avoid in elderly patients where possible. Warn against driving and alcohol use.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clemastine
Frequently asked questions
Can I take Clemastine with Estazolam?
MediHelp rates the interaction as moderate. Clemastine and Estazolam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Estazolam is a benzodiazepine hypnotic and clemastine is a sedating antihistamine. Together they can produce greater drowsiness, dizziness, impaired coordination and next-day impairment, with increased fall risk in older patients.
How serious is the interaction between Clemastine and Estazolam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses and avoid in elderly patients where possible. Warn against driving and alcohol use.
What other medicines interact with Clemastine?
MediHelp also lists interactions of Clemastine with, for example, Alfentanil, Benzhydrocodone / acetaminophen, Buprenorphine buccal. The full list is on the Clemastine page.
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