Drug interactions
Clemastine + Glycopyrronium tosylate
Severity: Moderate
Clemastine and Glycopyrronium tosylate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Glycopyrronium tosylate is applied topically for axillary hyperhidrosis and has some systemic absorption. With clemastine, which has anticholinergic activity, additive effects such as dry mouth, blurred vision, urinary retention and constipation may occur.
What this interaction means in plain words
Clemastine and Glycopyrronium tosylate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive antimuscarinic effects.
What to do
Monitor for anticholinergic adverse effects such as urinary hesitancy and visual disturbance. Stop glycopyrronium if significant symptoms develop.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clemastine
Frequently asked questions
Can I take Clemastine with Glycopyrronium tosylate?
MediHelp rates the interaction as moderate. Clemastine and Glycopyrronium tosylate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Glycopyrronium tosylate is applied topically for axillary hyperhidrosis and has some systemic absorption. With clemastine, which has anticholinergic activity, additive effects such as dry mouth, blurred vision, urinary retention and constipation may occur.
How serious is the interaction between Clemastine and Glycopyrronium tosylate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for anticholinergic adverse effects such as urinary hesitancy and visual disturbance. Stop glycopyrronium if significant symptoms develop.
What other medicines interact with Clemastine?
MediHelp also lists interactions of Clemastine with, for example, Alfentanil, Benzhydrocodone / acetaminophen, Buprenorphine buccal. The full list is on the Clemastine page.
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